C-myc and N-myc in the developing brain
نویسندگان
چکیده
منابع مشابه
C-myc and N-myc in the developing brain
(KO) of myc genes have provided substantial insight into not only their normal functions during development, but also shed light on their tumorigenic functions when they are misregulated. c-myc and N-myc genes both are essential in neural stem and precursor cells (NSC) for normal mouse brain growth[1, 2]. The fact that mutation of N-myc also causes microcephaly in humans in Feingold Syndrome[3]...
متن کاملComparison of the Initial Treatment Results of N-myc Positive and N-myc Negative Neuroblastoma Patients
Background: Neuroblastoma is the most common extra cranial malignant solid tumor of childhood. Various molecular and cytogenetic factors have been implicated in the pathogenesis of neuroblastoma, some of which have proven useful in predicting clinical behavior. Over expression of the oncogen N-myc, is an important indicator of prognosis. Materials and Methods: Our study was performed from 20...
متن کاملc-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain
myc genes are associated with a wide variety of human cancers including most types of nervous system tumors. While the mechanisms by which myc overexpression causes tumorigenesis are multifaceted and have yet to be clearly elucidated, they are at least in part related to endogenous myc function in normal cells. Knockout (KO) of either c-myc or N-myc genes in neural stem and precursor cells (NSC...
متن کاملAmplification units containing human N-myc and c-myc genes.
The amplification units in human tumors containing amplified myc genes were examined. The amplification unit in all cases consisted of a large genomic region coamplified with the coding region of the myc genes themselves. In eight independent neuroblastomas containing N-myc amplifications, the amplification unit was estimated to be 290 to 430 kilobases. This amplification unit was highly conser...
متن کاملcomparison of the initial treatment results of n-myc positive and n-myc negative neuroblastoma patients
background: neuroblastoma is the most common extra cranial malignant solid tumor of childhood. various molecular and cytogenetic factors have been implicated in the pathogenesis of neuroblastoma, some of which have proven useful in predicting clinical behavior. over expression of the oncogen n-myc, is an important indicator of prognosis. materials and methods: our study was performed from 2004 ...
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ژورنال
عنوان ژورنال: Aging
سال: 2010
ISSN: 1945-4589
DOI: 10.18632/aging.100151